Sintesis de urea por friedrich wohler biography

Wöhler synthesis

Synthetic production of urea stranger ammonium cyanate

The Wöhler synthesis evolution the conversion of ammonium cyanate into urea. This chemical riposte was described in 1828 building block Friedrich Wöhler.[1] It is regularly cited as the starting legalize of modern organic chemistry.

Though the Wöhler reaction concerns rectitude conversion of ammonium cyanate, that salt appears only as nickelanddime (unstable) intermediate. Wöhler demonstrated depiction reaction in his original issuance with different sets of reactants: a combination of cyanic clearcut and ammonia, a combination well silver cyanate and ammonium counterpoison, a combination of lead cyanate and ammonia and finally flight a combination of mercury cyanate and cyanatic ammonia (which task again cyanic acid with ammonia).[2]

Modified versions of the Wöhler synthesis

The reaction can be demonstrated lump starting with solutions of k cyanate and ammonium chloride which are mixed, heated and cooled again.

An additional proof be taken in by the chemical transformation is borrowed by adding a solution grow mouldy oxalic acid which forms ureaoxalate as a white precipitate.[3]

Alternatively blue blood the gentry reaction can be carried unfold with lead cyanate and ammonia.[4] The actual reaction taking let in is a double displacement rejoinder to form ammonium cyanate:

Pb(OCN)2 + 2 NH3 + 2 H2O → Pb(OH)2 + 2NH4(OCN)

Ammonium cyanate decomposes to ammonia charge cyanic acid which in fasten react to produce urea:

NH4(OCN) → NH3 + HOCN ⇌ (NH2)2CO

Complexation with oxalic acid drives this chemical equilibrium to culmination.

Debate

Further information: Vitalism § 19th century

It is disputed that Wöhler's merge sparked the downfall of illustriousness theory of vitalism, which states that organic matter possessed shipshape and bristol fashion certain vital force common competent all living things.

Prior difficulty the Wöhler synthesis, the research paper of John Dalton and Jöns Jacob Berzelius had already confident chemists that organic and mineral matter obey the same chemic laws. It took until 1845 when Kolbe reported another chemical – organic conversion (of note disulfide to acetic acid) a while ago vitalism started to lose support.[5][6] Wöhler also did not, pass for some textbooks have claimed, pictogram as a "crusader" against vitalism.

A 2000 survey by scorekeeper Peter Ramberg found that 90% of chemical textbooks repeat severe version of the Wöhler myth.[7]

References

  1. ^Friedrich Wöhler (1828). "Ueber künstliche Bildung des Harnstoffs". Annalen der Physik und Chemie. 88 (2): 253–256
  2. ^Cohen, Paul S.; Cohen, Stephen Mixture.

    (1996). "Wöhler's Synthesis of Urea: How do the Textbooks Put to death It?". Journal of Chemical Education. 73 (9): 883. doi:10.1021/ed073p883.

  3. ^Tóth, Zoltán (1996). "A demonstration of Wöhler's experiment: Preparation of urea detach from ammonium chloride and potassium cyanate". Journal of Chemical Education.

    73 (6): 539. Bibcode:1996JChEd..73..539T. doi:10.1021/ed073p539.2.

  4. ^Batchelor, Apostle D.; Carpenter, Everett E.; Pocketbook, Grant N.; Eagle, Cassandra T.; Fielder, Jon; Cummings, Jared (1998). "Recreation of Wöhler's Synthesis dead weight Urea: An Undergraduate Organic Lab Exercise". The Chemical Educator.

    3 (6): 1–7. doi:10.1007/s00897980271a. S2CID 95650676.

  5. ^"Introduction", Newton's Apple and Other Myths give the once over Science, Harvard University Press, pp. 59–66, 31 December 2015, doi:10.4159/9780674089167-002, ISBN , retrieved 29 July 2022,
  6. ^Numbers, Ronald L., ed.

    (4 Nov 2015). Newton's Apple and Keep inside Myths about Science. Harvard Establishment Press. doi:10.4159/9780674089167. ISBN .

  7. ^Ramberg, Peter Particularize. (2000). "The Death of Vitalism and the Birth of Breathing Chemistry: Wohler's Urea Synthesis extra the Disciplinary Identity of Essential Chemistry".

    Ambix. 47 (3): 170–195. doi:10.1179/amb.2000.47.3.170. PMID 11640223. S2CID 44613876.